To implement the 15-minute city (15mC) concept in urban areas, we need to rethink and reorganise our mobility systems. Digitalisation is a key factor in this process, with digital twins being one of the promising technologies to be utilised. We aim to explore this potential by developing a generic digital twin framework that allows us to model interventions in the urban transport system, explore and simulate their impact, and evaluate their contribution towards the realisation of a 15mC. In this, a special focus is put on human-centred approaches.